Reme-kolon is a medicine for benign ulcerative colitis.

Indications:

Inflammation of colon, dysentery, diarrhea and related ulcerative indications.

Composition:

Name                                 Latin Name                                Quantity

Bilva                                  Aegle Marmelos                          60mg

Vansha                              Bambusa Arundinacea                 20mg

Mochras                            Bombax Malabaricum                 20mg

Laksha                               Cateria Lacca                             20mg

Musta                                 Cyperus Rotundus                      40mg

Katuja                                Holarrhena Antidysentrica            60mg

Nagkesar                            Mesua Ferrea                              60mg

Anar                                   Punica Granatum                          60mg

Lodhra                                Symplocosa Racemosa                60mg

Dhatki                                 Woodfordia Fruticosa                  40mg

Ajmoda                               Trachyspermum Ammi                 40mg

Shatavari                             Asparagus Racemosus                  20mg

Dosage:

2 Capsules 3 times daily along with

REME-HELKOS – 2 capsules twice daily.

THERAPEUTIC NOTES

Aegle Marmelos (Bilva):

The fruits are used in chronic diarrhea and dysentery; also in colitis. In the after-treatment of bacilliary dysentery, the fruit is a useful adjuvant, as it helps to remove constipation, which hinders the healing of ulcerated surfaces of intestines. Exhibited anti-amoebic properties.

An Ayurvedic drug containing A. Marmelos, H. Antidysentrica, S. Racemosa, B. Malabarica and Aconitum Heterophyllum (Ativisha) was tried on 66 patients suffering from diarrhea. The drug showed encouraging results, as it was found to stop diarrhea even with first dose in some patients.

The efficacy of A. Marmelos was tested for the treatment of dysentery in 25 patients. All the patients were treated with powdered unripe fruits of A. Marmelos (5 g thrice daily for 21 days). Out of 25patients, 52% were completely cured, 44% improved and 4% remained unaffected.

Antimicrobial activity has been shown in the seed oil against bacteria and fungi. Antiprotozoal activity has also been shown by Henry and Brown. Hypoglycaemic activity of fruits has been reported.

In chronic dysenteric conditions, accompanied by loose stools alternating with occasional constipation, the ripe fruit is widely used in different formulations. Chronic diarrhea or dysentery responds well to bilva, this therapeutic effect being included in the British Pharmacopoeia. It is also been used for treating giardiasis. The bark and leaves are used in medicated retention enema. The root improves appetite and relieves nausea. It is also used as a mild sedative. Bilva has been used very widely for thousands of years in India. Occasionally constipation has been reported with larger doses of root bark. The extract of leaves has shown isotropic effects on the heart in experimental animals. Hypoglycemic effects have been reported.

Bambusa Arundinacea (Vamsa):

Mainly composed of silica 90.5, potash 1.1, alumina 0.4 and iron peroxide 0.9%. It is largely used as a cooling tonic. Stimulant, astringent, antispasmodic. Not much experimental work has been carried out on the plant. The young shoots contain 0.3 per cent hydrocyanic acid and are lethal to mosquito larvae.

Vansalochanam is used clinically for the treatment of praincha and given in combination with other drugs, relieves burning sensation.

Bombax Malabaricum (Mochras):

Credited with astringent, styptic, demulcent and tonic properties and is used for dysentery and haemoptysis. 30 patients of bleeding piles were treated with B. Malabaricum (2g in milk given twice daily). Complete cure was observed in 20(70%) cases, whereas a remarkable improvement was observed in 3(10%) cases. Marginal improvement was observed in 6(20%) cases.

Cateria Lacca (Laksha):

Tonic for liver, stomach and intestines. Haemostatic. Resolvent of obstruction. Cooling.

Cyperus Rotundus (Musta):

Stomachic, carminative, astringent, refrigerant, relieves thirst and heat of the body, useful in diarrhea, dysentery, disorders of the stomach and irritation of the bowels.

Holarrhena Antidysentricsa (Katuja):

A reputed drug for chronic dysentery and diarrhea. Specific for haemorrhoidal flux. A decoction of H. Antidysentrica and A. Marmelos fruit is found beneficial in mucous diarrhea with blood. The drug is generally combined with B. Malabaricum in acute and chronic dysentery and diarrhea. Seeds of H. Antidysentrica, A. Marmelos, B. Malabaricum, S. Racemosa and W. Fruiticosa are useful intestinal tonics, tone up intestines and the digestive system. Seeds of H. Antidysentrica and tubers of C. Rotundus enter into a composition prescribed for dysentery, diarrhea, flatulence, fever, bilious affections, piles, and intestinal worms.

A herbal composition of H. Antidysentrica, A. Marmelos, C. Rotundus and Embelia Ribes fruits, in a clinical trial on 25 patients of diarrhea and dysentery showed complete cure rate of 80% with an average 3.3 days treatment, without any toxic effect.

Mesua Ferrea (Nagkesar):

Astringent, stomachic, carminative. Useful in irritability of the stomach. Given in bleeding piles as well as dysentery with mucus.

The essential oil has antimicrobial and anthelmintic activity. Others have shown anti-inflammatory and antipyretic activity. Recently it has been shown that calophyllolide is effective in reducing the increased capillary permeability induced in mice by histamine, 5-HT and bradykinin. Main use of stamen has been described for controlling bleeding in menorrhagia and piles.

In a study By Meherjietal, the seed powder was used in a dose of three times a day for a period of 1 to 2 months. No untoward side effects were noticed in women. The plant has been widely used in India.

Punica Granatum (Anar):

Astringent, stomachic, digestive and highly effective in chronic diarrhea and dysentery, dyspepsia, colitis.

Antimicrobial evaluations of different solvent extracts from six plants (B. Aristata, B. Malabaricum, G. Herbaceum, H. Antidysentrica, M. Fragrans, P. Granatum) to being therapeutic agents in diarrhea and dysentery showed P. Granatum as most effective against four species of Shiegalla and E. Coli.

The anti amoebic activity of water-soluble factions of the rind and flowers of P.Granatum has been assessed by Naqvi, SAH, Dept. of Microbiology, Faculty of Sci. Hamdard University New Delhi, 1993. The in-vitro and in-vivo studies, carried out on a virulent strain of Entamoeba Histolytica, exhibited encouraging results. Good results were achieved with 40mg/ml and 20mg/ml rind and 5mg/ml, 4mg/ml, 2mg/ml flowers. Metronidazole served as a controlled drug. In-vivo P.Granatum-treated rats revealed normal cecum and intestines with no thickening or ulceration or any other lesions, and no motile trophozoites seen. No toxic effects were shown in the rats during the medication. In-vivo studies showed complete inhibition of growth of E.Histolytica after treating with rind 10mg per 10g body weight and flowers 25mg per 10g.

Punica granatum and pelletierine are evaluated as anthelmintics. The root bark also shows activity against tapeworms. Carraz Gilbert et al showed that the extract from Punica granatum was hypoglycaemic in mice. Astringent properties of the fruit rind and fruit juice explain the antidiarrhoeal activity.

The rind of the fruit is very useful in diarrhoea and dysentery. The fresh juice is used in cooling and refrigerant mixtures of some medicines for dyspepsia. The root bark has been used as an anthelmintic.

In the doses used and as a fruit no adverse reactions have been reported.

Symplocos Racemosa (Lodhra):

Astringent, carminative, useful in bowel complaints such as diarrhea and acute dysentery, fever, ulcers and swellings.

In a pharmacological study a crystalline fraction from the bark was found to inhibit the growth of Micrococcus pyogenes var. aureus, E. Coli and enteric and dysenteric groups of organisms. Another fraction from the bark was spasmogenic on the various parts of the gastro-intestinal tract.

Antimicrobial and pharmacological actions of some fractions obtained from the bark of S. Racemosa have been investigated. A crystalline fraction is found to inhibit the growth of staphylococci, E. coli, enteric and dysenteric group of organisms.

Woodfordia Fruticosa (Dhataki):

Purifies blood, heals ulcers, cures haematamesis, dysentery and diarrhea. Dried flowers are useful in disorders of mucous membranes, haemorrhoids and derangement of liver. Externally, powdered flower is sprinkled over foul ulcers and wounds for checking discharge and promoting granulations.

The flowers are useful in dysentery, diarrhoea, leucorrhoea and menorrhagia.

Trachysperma Ammi (Ajmoda):

Much valued for its antispasmodic, stimulant, tonic and carminative properties. It is given in flatulence, a chronic dyspepsia and diarrhea. It has been shown to possess antibiotic activity against Salmonella typhosa, Micrococcus pyogenes var. aureus and E. coli.

Asparagus Racemosus (Shatavari):

It is a refrigerant and antispasmodic. Allays internal heat, stomachic and the root is prescribed in bilious dyspepsia, chronic colic, diarrhea, dysentery and to promote appetite.

The effect of Safoof-e-Satavar, a composite Unani drug containing A. Racemosus as the principle ingredient, was tested in 30 cases of peptic disorders for 6 weeks. The relief in pain in epigastrium, nausea and vomiting, distention of abdomen, water brash, burning in epigastrium, insomnia due to pain and tenderness in epigastrium was found in 48.27, 93.34, 73.69, 62.07, 66.6, 46.67, 69.57 and 70.38 percent of cases respectively.

The aqueous extracts of both fresh and dried roots were found to have amylase & lipase activities. An effective drug in hyperacidity and potent gastric sedative.

In the doses of the root powder used clinically no adverse reactions have been reported. The bark of the plant is reported to be toxic.